6-Deoxyilludin M, a new antitumor antibiotic: Fermentation, isolation and structural identification.
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چکیده
منابع مشابه
UCH9, a new antitumor antibiotic produced by Streptomyces: I. Producing organism, fermentation, isolation and biological activities.
We developed a microbial prescreen using Bacillus stearothermophilus NUB3620 and bacteriophage TP-68 to detect potential antitumor compounds acting on DNA or topoisomerases. During the course of screening microbial cultures for their antibacteriophage activities, we found that Streptomyces sp. isolated from a soil sample collected in Iwakuni city, Yamaguchi prefecture, Japan, produced a new ant...
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Thrazarine, O-[(3R)-2-diazo-3-hydroxybutyryl)]-L-serine, is a new antitumor antibiotic produced by Streptomyces coerulescens MH802-fF5. Thrazarine was isolated from culture filtrate by Sephadex LH-20 column chromatography and reversed phase HPLC. Thrazarine induced cytolysis of tumor cell lines co-cultured with nonactivated macrophages. This effect was tumor specific because the nontumorigenic ...
متن کاملLeinamycin, a new antitumor antibiotic from Streptomyces: producing organism, fermentation and isolation.
Leinamycin (DC 107) is newly discovered antitumor antibiotic with an unusual 1,3-dioxo-1,2-dithiolane structure. Five different producing strains were isolated from soils collected in Japan during 1985-1988 and were taxonomically assigned as Streptomyces. Fermentation studies indicate: Leinamycin was unstable in culture broth. A chemically defined medium could be designed for a preferable produ...
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The LL-D05139 complex, containing LL-D05139 beta and azaserine, was recovered from the fermentation filtrate of Glycomyces harbinensis (NRRL 15337). A chemically defined medium was developed which favored the production of LL-D05139 beta. Antibiotic LL-D05139 beta was isolated from the fermentation filtrate by adsorption on granular carbon and further purified by chromatography on microcrystall...
متن کاملHeneicomycin, a new antibiotic (A21A): fermentation, isolation, and antibacterial spectrum.
In the course of our screening for new antibiotics, we have found heneicomycin (antibiotic A21A)1) in culture broth of a newly isolated strain of Streptomyces filipinensis, designated NRRL #11044 (MA-4581 in the Merck & Co., Inc. culture collection). From the physico-chemical and biological properties described in this communication, heneicomycin is considered to be equivalent to 3-deoxyaurodox...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1987
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.40.1643